The Study of Histological & Quantitative Changes on the Ovaries the Albino Mice Resulting From the Adriamycin Drug Dr.Anas Taweelh

Abstract:

Adriamycin is one of the most anti-cancer drugs used in cancerous tumors treatment, and
at the same time, is the least cytotoxic.
However, the identification of toxicological and histological side effects of this drug still
needs much research works to go. Accordingly, this study illustrates the negative impacts
caused by the drug on both histological structures of ovaries and ovarian follicles.
This study has shown affected by cellular and tissue structure on the granulosa cells for
example; the karyorrhexis of nuclei in granulosa cells, and shrinkage cytoplasm structure has
lost its interactions, some alterations in the theca follicle structure, especially the shape of cells
and their nuclei which became fusiform. And from the changes in the features and structure ofthe egg in the level of each follicle. an absence of Oocytes nuclei and regression of the cellular
membrane and finally cytoplasm
Those changes have been accompanied by a gradual regression in both weights and sizes
of ovaries and bodies of all experimented animals directly after the drug has been injected until
the 10th day. But Some ameliorations have been observed in all studied groups after the 10th day of injection

Researches Journal of Aleppo University, Basic Science Series, Vol:69, اسم المجلة 2010

http://www.alepuniv.edu.sy/content/journal-issue/69- رابط المجلة 0

البحث الخامس

Preventing the Side Effects of Adriamycin Drug on Histological Structure of the Ovaries in Syrian Hamster Using Honey and Royal Jelly Mixed with the Roots of the Ginseng Herb Dr.Anas Taweelh

Abstract: Adriamycin drug is used in the treatment of the cancer tumors, especially the
breast cancer, and because of its side effects on the sexual reproductive cells, this study came to
illustrate the possibility of preventing these side effects by the natural pharmacological products
as natural honey and royal jelly mixed with Ginseng roots. This study showed the contribution
of these natural compounds in maintaining the vitality of the ovary, the histological structure of
the mature vesicles (Graafian follicles), the Oocyte, so contributing in maintaining the
production of high-level ovarian hormones, and the ovarian cycle without disturbance, hence,
preventing the early menopause in females (sexual sterility). This study showed also an increase
in the ovulation stage compared to the group injected with the drugs without a protective dose.

On Journal of King Abdul Aziz Bulletin “Science” Vol: 26, No.1 July اسم المجلة 2014
https://platform.almanhal.com/Files/2/ رابط المقالة 69994
https://www.researchgate.net/publication/295243338_Preventing_the_Side_Effects_of_Adri
amycin_Drug_on_Histological_Structure_of_the_Ovaries_in_Syrian_Hamster_Using_Honey_
and_Royal_Jelly_Mixed_with_the_Roots_of_the_Ginseng_Herb?_sg=yKu9meVcjFJD8vTZIrmfVwQO-
hYyEpP8qfhbXNDyBeBq6XBVO55IgcOV5WOtfi4cP-JATAg3P8eRcs

البحث الرابع

The importance of honey with royal jelly and ginseng in the prevention of sex hormones disorders, and infertility caused by Adriamycin drug .Dr. annas taweelh

Abstract

Despite the importance of chemical drugs in the treatment of cancerous tumors, they have
different side effects. Adriamycin drug is considered one of the most commonly used drugs in
the treatment of breast cancer in women. The most important side effects that women face are
the impaired reproductive ability, hormonal and menstrual disorders, and their approach in
some cases to early menopause.
Therefore, it very important to study the possibility of addressing these effects through the
use of natural pharmaceuticals. This study showed that giving preventive doses of Honey with
royal food, mixed with the roots of ginseng, have contributed to maintaining the vitality of the
ovaries of the toxic effects. So this will lead to an increase in the level of ovarian hormones,
preserving the ovarian cycle, and preventing the approach to the stage of ovarian sexual
infertility. Moreover, it has increased the number of ovulation phases, and also the fertility rate.

Arab Journal of Pharmaceutical Sciences, No:2,Vol:5, Fep  2015
http://new.damascusuniversity.edu.sy/faculties/pharm/images/stories/collection/magazen 2

البحث الثالث

 

THE ROLE OF HONEY WITH ROYAL JELLY IN PROTECTING THE GRAAFIAN FOLLICLES FROM THE TOXICITY OF THE ADRIAMYCIN DRUG TAWEELH ANAS

ABSTRACT
Objective: This study aims to investigate the ability of certain mixture of honey with royal jelly (H+R) to prevent the toxic side effects, caused by the
Adriamycin drug. One of the most important side effects of this drug is the change in the structure of cell and tissue of the ovary, especially Graafian
follicles, which may lead to sexual ovarian hormonal disorders. Consequently, this will lead to menstrual disorders that lead in certain cases to early
menopause (infertility), and decrease in the reproductive capacity.
Methods: Twenty-five young adult female Syrian hamsters were injected with (60-75 mg/mP
2
P )Aderiamycin drug and another twenty-five females
were injected with Adriamycin drug after oral administration with preventive dose of honey and royal jelly (800 mg/kg/day of Honey and 10
mg/kg/day of royal jelly). Histologically study of the ovaries was conducted with hymatoxylin & eosin staining, and an immunohistochemical study
was applied using the immune. (Ki67) specialized for disclosure of cell divisions.
Results: The honey with royal jelly has a clear role in renovating the ovary, enhancing the hormonal balance, and prevents the hormonal disorders,
and the occurrence of early menopause caused by Adriamycin.
Conclusion: The Honey with royal jelly contributes, as a preventive dose, in preventing the side effects of Adriamycin drug.
Keywords: Adriamycin, Graafian follicles, Honey, Royal jelly, Syrian hamster.

KASSEM MAHMOUD, TAWEELH ANAS*
Comparative anatomy Lab-Department of Biology-Faculty of Science-Aleppo University Aleppo – Syria.
Email: Anastaweelh83@gmail.com
Received: 11 Dec 2014 Revised and Accepted: 01 Jan 2015.البحث الثاني

https://innovareacademics.in/journals/index.php/ijpps/article/view/ رابط المقالة 4364

Green Production of Dental Materials and the Needs for aLeast-Toxic Dentistry Fendi Alshaarani

Loai Aljerf1* and Fendi Alshaarani2
1Department of Basic Sciences, Damascus University,
Syria
2Department of Fixed Prosthodontics, Alhwash
University, Syria
*Corresponding author: Loai Aljerf, Department of
Basic Sciences, Faculty of Dental Medicine, Damascus
University, Damascus, Syria
Received: February 21, 2019; Accepted: March 01,
2019; Published: March 08, 2019

Measuring Speed of Sound as a Safe Technique for the Investigation of Bone Graft Healing in Maxilla Suleiman, Waleed;* Mashlah, Ammar;† Al-Haffar, Iyad.‡

Abstract:

Background: Depending on the insufficiency of radiographic techniques in investigating changes in grafted sites, this study aimed to evaluate the ability of measuring speed of sound (SOS) as a safe technique for the evaluation of bone graft healing.

Materials and Methods: A total of 20 patients in need of sinus augmentation were recruited for this study. Cone-beam CT scans were obtained presurgically, after 4 months, and after 6 months from surgery per patient. A hydroxyapatite HA and tricalciumphosphate TCP (75:25) grafts were applied for sinus elevation. Speed of Sound (SOS) measurements within the grafted sites were performed in bucco-palatal direction presurgically, directly after surgery, 6 weeks, 3 months, 4 months and 6 months after surgery. At the time of implant placement, bone core biopsies were harvested and sections from the graft core were histomorphometrically analyzed. The new vital bone formation %VB was correlated with SOS measurement outcomes using a statistical model.

Results: Twenty patients underwent sinus augmentation for a total of 20 sinuses. Two sinuses developed an infection after grafting resulting in a 90% success rate for the sinus grafting procedure. An 18 sinuses were used in the final statistical analysis. SOS measurements revealed a mean of 1538.18±28.02 m/s directly after surgery and 1794.21±43.54 m/s after 6 months. Histomorphometric analysis revealed that mean %VB was 20.64±5.36, mean percent of remaining graft material was 23.67±2.99, and average percent of non-mineralized connective tissue was 55.68±4.29. SOS values significantly correlated with %VB (r =0.696, P<0.001). No correlation found between radiographic density of the grafted sites after 6 months and SOS or histomorphometric results.

Conclusions: Measuring sound transmission velocity within the grafted sites is a safe and active technique for the expression of graft content changes and structure and evaluating graft healing.

Keywords: Cone-beam CT, speed of sound, graft, density.DOC-20190406-WA0003

A statistical study of the relationship between blood groups and educational achievement in a random sample of students of Al-Hawash Private University Research submitted to obtain a Bachelor’s Degree in Pharmacy Prepared by: Bashar Deeb, Laila Bishara, Emad Jabbour and Hala Shaar Supervision Prof.Ge0rgeos Deeb

Introduction
A number of studies have dealt with the relationship between the blood groups and the level of educational attainment among the different peoples. Despite the limited number of these studies, the results were different for the contrasting ones.
A study of a sample of medical students in South India showed a difference in the level of educational achievement among the various blood groups, especially those in group A who had higher academic achievement compared to other groups. However, these differences were not statistically significant (2017) Srivastava N , Yadav
On the other hand, another study of the relationship between the blood groups and each of the average rate of achievement and the level of educational attainment among students of a number of Jordanian universities (Jerash University, University of Jordan, Yarmouk University, Philadelphia University, Irbid National University and Balqa Applied University) (IQ) and the highest level of scientific achievement (AGPA) compared to other groups, while the IQ and level of achievement of students in the lower B group compared to other groups (2014 Mohumad Saleh Atoom).
Thus, when we look at the few available data and regardless of their contradictions, we note that many aspects of the relationship between the blood groups and the rate of educational attainment remain unclear. Moreover, no study has been conducted in Syria on the issue.

Objective of the study: The aim of the study is to examine the potential relationship between the blood groups and the level of educational attainment in a random sample of students of Al-Hawash Private University.

Materials and Methods of Study
Place of study: Al Hawash Private University – Faculty of Pharmacy
The study was conducted in random sample of 550 students (359 males and 195 females) A group of healthy students at the Faculty of Pharmacy with ages ranging between 19-24 years
The venous blood sample was taken after a fasting period of not less than three hours by sterile syringes (3 cm) and collected in special tubes with anticoagulant (EDTA) and kept in the fridge at a temperature of 4 m.
Blood groups were determined using a standard antibody.

Determine the level of achievement of each student through his / her cumulative average (AGPA) obtained from his or her student record.

The data and indicators studied were statistically treated using Excel
Microsoft.

Summary of research findings

 The descending order of the frequency of blood groups in male and female students with a mean of 2 or higher was as follows: Group A followed by O followed by B and AB.
The proportion of females with group A was higher than their male counterparts by about 8%, while the proportion of males in group B was higher than their female counterparts by about 6%
 The descending order of distribution of blood groups in all students with a mean of 2 or higher expressed in percentage of the total number of students with the same blood group was as follows: Group A and then B followed by AB followed by the percentage of females was higher than males in all groups
 The descending order of the frequency of blood groups in students with a mean of 3 or higher was as follows: Group A, then O, then B and AB, and the percentage of females was higher than that of males in all groups except group B where males were higher than females.
 The descending order of blood group frequency in students with a mean of 3 or higher expressed in percentage of the total number of students with the same blood group was as follows: Clusters AB, A, B, O
The proportion of females was higher than that of males, where the proportion of females who hold the group AB 25% of the total female population who have the same group
 The descending order of frequency of blood groups in students below 2 was as follows: group A, A, B, and AB.
The percentage of group O was close among males and females, while the percentage of group A in the female peers male, while the proportion of groups AB, B was higher in males than females
 The descending order of blood group frequency in students below 2 expressed in the percentage of total students with the same blood group was as follows: AB, then O followed by B, A.
The percentage of males was higher than that of females in all groups, especially group A, B
 The descending order of the frequency of blood groups in students with a mean of less than 1 was as follows: group A, A, B, AB.
The percentage of males was higher than the percentage of females except group O where the proportion of females is higher than males.
-The descending order of blood group frequency in students with less than one percent of the total number of students with the same blood group was as follows: Group B, B, O, A. The percentage was higher among males than among females in all groups.بحث العلاقة بين الزمر الدموية ومستوى التحصيل العلمي لدى طلاب كلية الصيدلة عربي

Study of the Relationship Between Blood Groups and Anemia in a Sample of Students at Al-Hawash Private University Research submitted to obtain the degree of leave in pharmacy Prepared by: Bashar Deeb, Laila Bishara, Emad Jabbour, Hala Shaar Supervisor: Prof. Ge0rgeos Deeb

Introduction
A few studies have examined the relationship between blood groups and smoking. A study of the relationship between blood groups and smoking indicates study indicates that individuals belonging to the blood groups B, A or AB are more susceptible to anemia than those with blood group O (Basak Asim Kumar, and Maji Kaushik 2013)
Little data available on the relationship between blood groups and anemia, let alone, no study in Syria has been conducted on this issue.
The aim of the study is to study the potential relationship between blood groups and smoking in a random sample of students of Hawash Private University.
Objective of the study: The aim of the study is to study the potential relationship between blood groups and anemia in a random sample of students of Hawash Private University.

Materials and Methods of Study
Place of study: Al-Hawash Private University – Faculty of Pharmacy
The study was conducted in random sample of 550 students (359 males and 195 females) healthy students from the Faculty of Pharmacy at Hawash University for ages 19-24 years
The venous blood sample was taken after a fasting period of not less than three hours by sterile syringes (3 cm) and collected in special tubes with anticoagulant (EDTA) and kept in the fridge at a temperature of 4 m.
Blood groups were determined using a standard antibody. Number of erythrocytes, hematocrit, hemoglobin concentration,mean cell hemoglobin MCH, and Mean corpuscular volume MCV were measured by automated counter: Fully Automatic Hematology Analyzer-Double Channel and 3part WBC HA04 Manufacture of Rehab Medical.
The data and indicators studied were statistically treated using Excel Microsoft.
Results
The study of hemoglobin concentration showed that the mean concentration of males was (15.3 g / 100 ml) and females (12.4 g / 100 ml) located in the normal area.
In analyzing the concentration of hemoglobin in both males and females, the proportion of males with hemoglobin concentration within the range (13-18 g / 100 ml) was 95.5%, higher than the percentage of females who had hemoglobin concentrations within the same range (11.5-16.5) g / 100 ml) which is 80.5%. The percentage of females with hemoglobin concentration below 11.5 g / 100 ml was 19.5%, higher than their male counterparts (hemoglobin concentration less than 13 g / 100 ml) by 15.6%. In contrast, females did not have any case of concentration of hemoglobin higher than both, while in males it was 0.6%.
An analysis of the pattern of anemia in males shows that 64.3% of the patients have normochromic normocytic anemia (MCH in the range 26-36 kg and MCV in the area 76-96 mm) and 35.7% have hypochromic microcytic anemia (MCH below 26 pg and MCV below 76mcmᶟ).
In females, the percentage of patients with normochromic normocytic anemia was 47.4% and percentage of patients with hypochromic microcytic anemia was 39.5%.
The results of analysis of the relationship between blood groups and concentration of hemoglobin show that 95% of the male students with groups A, B, O have normal hemoglobin, while all the male students with the group AB have normal hemoglobin. On the other hand, the percentage of females with normal hemoglobin in the different of the group ABO as follows: AB: (87.5%), O: (82.4%), B: (82.1%), A: (77.6%).
In contrast, the analysis of blood groups in students with anemia showed that the frequency of blood groups in the women with anemia for the total number of females carrying the same group was as follows:
• Group A (22.4%) of the total number of female students with the same blood group.
• Group O (17.6%) of the total number of female students who have the same blood group.
• Group B (17.9%) of the total number of female students with the same blood group.
• Group AB (12.5%) of the total number of female students who have the same blood group
In contrast, the percentage of male students diagnosed with anemia was as follows:
• Group A (4.5%) of the total number of male students with the same blood group.
• O group (4.3%) of all male students with the same blood group.
• Group B (3.1%) of all male students with the same blood group.
• Males with anemia were not reported to have the AB group
In the Rh group, no significant differences were observed in mean hemoglobin concentrations in males and females positive and negative Rhizos.
Students with the AB + group had the highest percentage of male hemoglobin concentrations (16.1 g / 100ml).
Students with A-group have the lowest percentage of mean hemoglobin concentrations in males (g / 100ml14.6).
In general, the mean hemoglobin concentration was higher than 15 g / 100ml in all blood groups except group A for males.
Female students had an average hemoglobin concentration of 12.1-12.5 g / 100ml in all blood groups except the O-group, with mean hemoglobin concentrations of 11.8 g / 100ml.العلاقة بين الزمر الدموية وفقر الدم

Study of the Relationship between Blood Groups and Smoking in a Sample of Students at Al-Hawash Private University Research submitted to obtain a Bachelor’s Degree in Pharmacy Prepared by: Bashar Deeb, Laila Bishara, Emad Jabbour and Hala Shaar Supervision Prof.Ge0rgeos Deeb

العلاقة بين الزمر الدموية والتدخينIntroduction
A few studies have examined the relationship between blood groups and smoking. A study of the relationship between blood groups and smoking indicates that the frequency of group B is high in smokers (Higgins, et al.(
Little data available on the relationship between blood groups and smoking, let alone, no study in Syria has been conducted on this issue.
The aim of the study is to study the potential relationship between blood groups and smoking in a random sample of students of Hawash Private University.
Materials and Methods:
Place of study: Al Hawash Private University – Faculty of Pharmacy
The study was conducted in random samples of 550 students (359 males and 195 females) healthy students from the Faculty of Pharmacy at Al-Hawash Private University for ages 19-24 years
The venous blood sample was taken after a fasting period of not less than three hours by sterile syringes (3 cm) and collected in special tubes with anticoagulant (EDTA) and kept in the fridge at a temperature of 4 m.
Blood groups were determined using a standard antibody.
The data and indicators studied were statistically treated using Excel Microsoft

Results
The percentage of students who smoked was 73.4% (404 out of 550 students, 288 males and 120 females). The distribution of the blood groups in Figs. 1,2,3,4 and 5 was as follows:
• Group O 41.3% (41% males, 42.2% female) and constitute 78.4% of the total number of students with the same group (84.9% males, 66.2% females).
• Group A 36.6% (35.4% male, 39.7% female) and constitute 67.6% of the total number of students with the same group (76.2% male, 54.1% female).
• Group B 16.8% (18.1% male, 13.8% female) and constitute 73.1% of the total number of students with the same group (80% male, 57.1% female).
• Group AB 5.2% (5.7% males, 4.3% females), constituting 72.4% of the total number of students with the same group (76.2% males, 62.5% females).
The proportion of female smokers with A and O is slightly higher than their male counterparts, and the proportion of male smokers with group B, AB, is higher than that of females.
The percentage of males and females in males and females is shown in Figs 7,8,9 as follows:
The percentage of smokers with the O + group was the highest in both males and females.
The percentage of smokers with group A + was higher among females (37.1%) than male counterparts (32.3%).
The proportion of smokers with B + was higher among males (15.3%) than female counterparts (12.1).
The percentage of smokers with group AB + was higher for males (5.6%) than for females (4.3%).
The percentage of smokers with group A was 2.8% in males and 1.7% in females.
The percentage of group O – was 1.4% for males and 2.6% for females.
The analysis of the blood group ABO and RH in both males and females is expressed as a percentage of the total number of students with the same blood group as shown:
• The percentage of the group O + 79.6% (86.4% male, 66.7% female) of the total number of students with the same group.
• The percentage of group B + 73.4% (81.5% males, 56.0% females) of the total number of students with the same group.
• The percentage of the group AB + 72.4% (76.2% males, 62.5% females) of the total number of students with the same group.
• The percentage of group B- 71.4% (72.7% males, 66.7% females) of the total number of students who have the same group.
• Group A + 68.3% (77.5% males, 54.4% females) of the total number of students with the same group.
• The percentage of group A-60.0% (64.3% males, 50.0% female) of the total number of students with the same group.
• The percentage of the group O-58.3% (57.1% male, 60.0% female) of the total number of students with the same group.
The results of the study show that the percentage of smokers with the O + group was highest in both males and females. In contrast, the percentage of male smokers who hold the O-group was lower among all groups. In addition, the proportion of female smokers who carry the group O – higher than the proportion of male smokers and those with the same blood group.
It was found that the proportion of male smokers was higher than that of females in all groups except the group O. The highest percentage of female smokers were those who have the group B-.