THE ROLE OF HONEY WITH ROYAL JELLY IN PROTECTING THE GRAAFIAN FOLLICLES FROM THE TOXICITY OF THE ADRIAMYCIN DRUG TAWEELH ANAS

ABSTRACT
Objective: This study aims to investigate the ability of certain mixture of honey with royal jelly (H+R) to prevent the toxic side effects, caused by the
Adriamycin drug. One of the most important side effects of this drug is the change in the structure of cell and tissue of the ovary, especially Graafian
follicles, which may lead to sexual ovarian hormonal disorders. Consequently, this will lead to menstrual disorders that lead in certain cases to early
menopause (infertility), and decrease in the reproductive capacity.
Methods: Twenty-five young adult female Syrian hamsters were injected with (60-75 mg/mP
2
P )Aderiamycin drug and another twenty-five females
were injected with Adriamycin drug after oral administration with preventive dose of honey and royal jelly (800 mg/kg/day of Honey and 10
mg/kg/day of royal jelly). Histologically study of the ovaries was conducted with hymatoxylin & eosin staining, and an immunohistochemical study
was applied using the immune. (Ki67) specialized for disclosure of cell divisions.
Results: The honey with royal jelly has a clear role in renovating the ovary, enhancing the hormonal balance, and prevents the hormonal disorders,
and the occurrence of early menopause caused by Adriamycin.
Conclusion: The Honey with royal jelly contributes, as a preventive dose, in preventing the side effects of Adriamycin drug.
Keywords: Adriamycin, Graafian follicles, Honey, Royal jelly, Syrian hamster.

KASSEM MAHMOUD, TAWEELH ANAS*
Comparative anatomy Lab-Department of Biology-Faculty of Science-Aleppo University Aleppo – Syria.
Email: Anastaweelh83@gmail.com
Received: 11 Dec 2014 Revised and Accepted: 01 Jan 2015.البحث الثاني

https://innovareacademics.in/journals/index.php/ijpps/article/view/ رابط المقالة 4364

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